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Case Study of physiotherapy treament of a patient with the diagnosis of dermatomyositis
Středová, Michaela ; Neuwirthová, Svatava (advisor) ; Jarošová, Hana (referee)
Title Case study of physiotherapy treament of the patient with the diagnosis of dermatomyositis. Objectives The aim of this work is to process knowledge for dermatomyositis and evaluation of approaches which are presented in the literature mentioned below. Second objective was to evaluate the impact of physiotherapy treatment for this disease. Methods The general part of the thesis includes theoretic knowledge about dermatomyositis. In the second part of this thesis I processed the case of a patient diagnosed with dermatomyositis under the leadership of an experienced physiotherapist for 10 days Results We have achieved quite a significant improvement. Treatment included physical therapy and pharmacological treatment with corticoids. Corticoids have partial portion of the over-all result. Keywords Dermatomyositis, polymyositis, muscle weakness.
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Immunogenetic and hormonal markers of predisposition to systemic rheumatic diseases particularly systemic lupus erythematosus
Fojtíková, Markéta ; Pavelka, Karel (advisor) ; Hrnčíř, Zbyněk (referee) ; Rovenský, Jozef (referee)
Fojtikova 2011 INTRODUCTION: Several factors like genetic susceptibility is required for systemic rheumatic diseases development. Immunomodulatory PRL effect supports autoimmunity. AIMS: 1. To detect the immunogenetic background (alleles HLA class I, II and microsatellite polymorphism of the transmembrane part exon 5 of MIC-A gene) of SLE and PsA. 2. To detect PRL serum and synovial fluid with regard to clinical and laboratory RA activity. 3. To find the role of the functional polymorphism -1149G/T SNP PRL of extrapituitary promoter of PRL gene in SLE, RA, PsA, SSc and inflammatory myopathies development. METHODS: Genetic analyses of pateints with SLE (n=156), RA (n=173), PsA (n=100), SSc (n=75), PM (n=47) a DM (n=68) and 123 healthy individuals: PCR-SSP (HLA clase I and II), PCR-fragment analysis (MIC-A) a PCR-RFLP (-1149 G/T SNP PRL). In 29 RA a 26 OA PRL serum and synovial fluid concentrations were detected using immunoradiometric assay. RESULTS: 1. The allele HLA-DRB1*03 (pc=0.008; OR 2.5) and haplotype HLA-DRB1*03-DQB1*0201 (pc <0.001; OR 4.54) were determined as risk immunogenetic markers for SLE in Czech population. In SLE versus controls allele MIC-A5.1 was increased (pc =0.005; OR 1.88). MIC-A5.1 together with HLA-DRB1*03 increases the risk for SLE development, pc <0.000001; OR 9.71....
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The effect of physical activity interventions on the course and activity of selected rheumatic diseases
Špiritović, Maja ; Tomčík, Michal (advisor) ; Horák, Pavel (referee) ; Soukup, Tomáš (referee)
Introduction: This work focused on two rare rheumatic diseases systemic sclerosis (SSc) and idiopathic inflammatory myopathies (IIM). Skin and musculoskeletal involvement in patients with SSc leads to disability and loss of functional abilities of an individual. Chronic inflammation of the muscles, subsequent muscle atrophy and permanent muscle damage in patients with IIM are the cause of a decrease in muscle strength and endurance. Moreover, both diseases also affect internal organs and manifest often with impaired lung and heart function. All of these involvements in both diseases lead to a decrease in the quality of life of patients. The data on efficacy of non-pharmacological care in SSc and IIM are very limited due to the heterogeneity of the studied interventions and/or outcomes. However, due to limitations in pharmacological therapy, non-pharmacological interventions could help bring patients back into their everyday life and improve their quality of life. Objectives: The main objective of this project was to evaluate the impact of physical intervention on disease course and activity in a substantial number of SSc and IIM patients, with the aim of minimizing the limitations of available studies, thereby improving the quality and reliability of the obtained results. Methods: This is a...
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BAFF (B-cell Activating Factor of the TNF Family) in patients with idiopathic inflammatory myopathieswith respect to autoantibody profile.
Kryštůfková, Olga ; Vencovský, Jiří (advisor) ; Tlaskalová - Hogenová, Helena (referee) ; Blažíčková, Stanislava (referee)
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of chronic muscle diseases with frequent extramuscular organ involvement that contributes to serious prognosis. The presence of autoantibodies and composition of muscle infiltrates both support autoimmune nature of the disease and pathogenic role of B lymphocytes. Besides the traditional diagnostic subgroups, autoantibody characterised phenotype subsets have been identified with presumed similar pathogenic mechanisms. The best known is the antisynthetase syndrome which is characterised by presence of myositis, antisynthetase autoantibodies (with anti-Jo-1 being the most frequent), interstitial lung disease and other extramuscular manifestations. BAFF (B cell-Activating Factor of the TNF Family) is a key factor in B cell homeostasis modulation. In high levels, it allows survival of autoreactive B cell clones and thus participates in the pathogenesis of autoimmune diseases. Its expression is induced by type I interferons (IFN-1). The aim of the PhD thesis was to explore the role of BAFF in pathogenesis of IIMs by analysis of its serum levels, the receptors for BAFF in muscle tissue, their associations to IFN-1 and expression of BAFF gene mRNA transcription variants in peripheral blood cells. Further aspect was to study a possible...
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Immunogenetic and hormonal markers of predisposition to systemic rheumatic diseases particularly systemic lupus erythematosus
Fojtíková, Markéta ; Pavelka, Karel (advisor) ; Hrnčíř, Zbyněk (referee) ; Rovenský, Jozef (referee)
Fojtikova 2011 INTRODUCTION: Several factors like genetic susceptibility is required for systemic rheumatic diseases development. Immunomodulatory PRL effect supports autoimmunity. AIMS: 1. To detect the immunogenetic background (alleles HLA class I, II and microsatellite polymorphism of the transmembrane part exon 5 of MIC-A gene) of SLE and PsA. 2. To detect PRL serum and synovial fluid with regard to clinical and laboratory RA activity. 3. To find the role of the functional polymorphism -1149G/T SNP PRL of extrapituitary promoter of PRL gene in SLE, RA, PsA, SSc and inflammatory myopathies development. METHODS: Genetic analyses of pateints with SLE (n=156), RA (n=173), PsA (n=100), SSc (n=75), PM (n=47) a DM (n=68) and 123 healthy individuals: PCR-SSP (HLA clase I and II), PCR-fragment analysis (MIC-A) a PCR-RFLP (-1149 G/T SNP PRL). In 29 RA a 26 OA PRL serum and synovial fluid concentrations were detected using immunoradiometric assay. RESULTS: 1. The allele HLA-DRB1*03 (pc=0.008; OR 2.5) and haplotype HLA-DRB1*03-DQB1*0201 (pc <0.001; OR 4.54) were determined as risk immunogenetic markers for SLE in Czech population. In SLE versus controls allele MIC-A5.1 was increased (pc =0.005; OR 1.88). MIC-A5.1 together with HLA-DRB1*03 increases the risk for SLE development, pc <0.000001; OR 9.71....
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Case study of physiotherapy treatment of a patient with dermatomyositis
Melicharová, Hana ; Maršáková, Kateřina (advisor) ; Jarošová, Hana (referee)
Title: Case study of physiotherapy treatment of a patient with Dermatomyositis. Aims: A summary of theoretical background, study of comprehensive rehabilitation methodology, proposal of therapy and evaluation of its effect in a patient with dermatomyositis. Methodology: Review of literature and case study was made during practice in Instute of Rheumatology in Prague from 9. 1. to 3. 2. 2012. It has two parts. Theoretical part sumarizes etiology, epidemiology, clinical manifestation, therapy and use of physiotherapy in dermatomyositis. A case study is presented in the special part. Therapeutical approach was prescribed according to the medical history and physical examination and its effect was assessed using kinesiology analysis at the end. Results: In my patient back pain was decreased and the trunk stability was increased. Also the overall physical fitness increased as well as the stereotype of gait and endurance. Positive motivation and results of therapy the patient improved patient access to rehabilitation in general. Key words: dermatomyositis, polymyositis, inflammatory myopathy, rehabilitation, physiotherapy, muscle weakness.
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Case Study of physiotherapy treament of a patient with the diagnosis of dermatomyositis
Středová, Michaela ; Neuwirthová, Svatava (advisor) ; Jarošová, Hana (referee)
Title Case study of physiotherapy treament of the patient with the diagnosis of dermatomyositis. Objectives The aim of this work is to process knowledge for dermatomyositis and evaluation of approaches which are presented in the literature mentioned below. Second objective was to evaluate the impact of physiotherapy treatment for this disease. Methods The general part of the thesis includes theoretic knowledge about dermatomyositis. In the second part of this thesis I processed the case of a patient diagnosed with dermatomyositis under the leadership of an experienced physiotherapist for 10 days Results We have achieved quite a significant improvement. Treatment included physical therapy and pharmacological treatment with corticoids. Corticoids have partial portion of the over-all result. Keywords Dermatomyositis, polymyositis, muscle weakness.
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